Virginia Research Day 2025

Medical Student Research Clinical

34 A Retrospective Cohort Analysis of Glucose Regulation in 418 Patients with Endometriosis

Cara Satoskar, OMS-II; Erin Onken, OMS-II; Elizabeth Yi, OMS-II; Kaitlyn McGinley, OMS-II; Maryam Zahid, OMS-II; Ramzi Badra, OMS-II; Leona Jafari, OMS-II; Anita Register, DO Corresponding author: csatoskar@vcom.edu

Edward Via College of Osteopathic Medicine - Virginia Campus

NIH-funded All of Us database. Patients missing key clinical or demographic information or with fewer than 10 individual blood glucose values were excluded. Propensity score matching was used to 1:1 match ENDO cases to non-ENDO controls based on race, ethnicity, BMI, type 1 diabetes mellitus status, and age. A two-tailed t-test compared average blood glucose levels between groups. Results: The final sample included 418 ENDO patients and 418 matched controls with balanced demographic and clinical characteristics. ENDO patients had a significantly lower mean glucose level of 144.92 mg/dL (SD = 42.21), compared to 152.37 mg/dL (SD = 49.95) in controls (p=0.02). The average

BMI was slightly higher in the endometriosis group (35.85 vs. 34.30 in controls), nearing significance (p=0.083). Both groups had a comparable prevalence of T1DM. Conclusions: This matched analysis showed that ENDO patients had significantly lower average glucose levels than matched controls. The modest yet statistically significant difference supports a possible link between ENDO and glucose regulation. Further research is necessary to investigate the biological mechanisms and implications of dysregulated glucose metabolism among ENDO patients.

Introduction: Endometriosis (ENDO), a chronic inflammatory condition characterized by the presence of endometrial tissue outside the uterine cavity, affects approximately 10% of reproductive-age females. Current literature suggests that dysregulated glucose may play a crucial role in the pathophysiology of ENDO, impacting both disease progression and quality of life. This retrospective cohort study aims to further elucidate the relationship between glucose metabolism and ENDO by examining average blood glucose levels and their potential association with the condition. Methods: An initial sample of 5,342 female patients with ENDO were identified from the

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