VCOM 2020 Annual Report

RESEARCH

Teresa Johnson, PhD • VCOM REAP Award: Isolation of antiviral and hemostatic factors from a naturally- occurring substance for treatment of viral infections and wounds of the dermis. Jim Mahaney, PhD, is an investigator on this study. Susan Meacham, PhD • VCOM REAP Award: Nutritional status in VCOM international service areas: a comparative analysis. Dean Sutphin, PhD, JuliSu Dimucci-Ward and Annie Kirby, PhD, RN, are investigators on this project. Pawel Michalak, PhD • VCOM REAP Award: IGPOHOM: An integrative genomics platform for one health and osteopathic medicine. Skip Garner, PhD, is an investigator on this study. • VCOM & VMCVM One Health Research Center Award: Integrative genomics of small noncoding RNAs in host- associated bacteria – Phase II. Dr. Michalak is Co-PI on this project with a colleague from VMCVM. • VCOM & VMCVM One Health Research Center Award: Nanopore- based deep sequencing to characterize Ixodes scapularis variants and their pathogenic microbiota. Dr. Michalak is Co-PI on this project with a colleague from VMCVM.

Govind Rajagopalan, PhD • VCOM REAP Award (matching funds from VT ICTAS): Delineating the molecular pathways that lead to liver failure during sepsis using humanized mice and multi-cellular 3D organotypic human liver cultures. Dr. Rajagopalan serves as Co-PI along with a colleague from VT ICTAS. • VCOM & VMCVM One Health Research Center Award: Profiling of human innate as well as adaptive immune responses to Brucella infection and vaccination using humanized mice to predict protective outcomes. A faculty member from VMCVM serves as Co-PI along with Dr. Rajagopalan. Research Center Award: Early growth response protein 2 (EGR2)-mediated epigenetic regulatory network in lupus. Dr. Reilly is Co-PI with a faculty member at VMCVM. • VCOM & VMCVM One Health Research Center Award: Modulation of the microbiota decreases disease in lupus mice. A colleague from VMCVM serves as Co-PI with Dr. Reilly on this project. Beverly Rzigalinski, PhD • VCOM REAP Award: Improving blood storage with cerium oxide nanoparticles. Chris Reilly, PhD • VCOM & VMCVM One Health

• VCOM REAP Award (matching funds from VT ICTAS): Evidence based approach for modeling osteopathic manipulative therapy in a rodent model. Dr. Rzigalinski serves as Co-PI with a colleague from VT Bioengineering and Mechanics. Al Kozar, DO, is an investigator on this study. Dean Sutphin, PhD • VCOM REAP Award: Third-generation DNA sequencing approaches to rapid characterization of drinking water contamination in Appalachia. Skip Garner, PhD, and Pawel Michalak, PhD, are investigators on this project. Robin Varghese, PhD • VCOM REAP Award: Bringing precision medicine to the anatomy lab. Tiffany Carpenetti, PhD, is the Co-PI on this project and Skip Garner, PhD; John Anstrom, PhD, and Ramu Anandakrishnan, PhD, are investigators.

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