Virginia Research Day 2025

Medical Student Research Public Health

01 Impact of Socioeconomic Status on Osteoarthritis Progression in Weight-Bearing Joints: An Analysis Using the All-of-Us Database

Osscar Gonzalez Sandoval, MS; Ramu Anandakrishnan, PhD; Micah Jones, DO; Michael Breiner, MD Corresponding author: ogonzalezsandoval@vt.vcom.edu

Edward Via College of Osteopathic Medicine - Virginia Campus

across these groups, controlling for age, sex, BMI, and comorbidities. Expected Outcomes: This research aims to establish a link between lower SES and faster OA progression, potentially highlighting mediating factors like occupational risks and healthcare accessibility. Findings may contribute to developing targeted intervention strategies to slow OA progression in vulnerable populations.

Abstract: This study investigates the correlation between socioeconomic status (SES) and the progression of osteoarthritis (OA) in weight-bearing joints, using data from the All-of-Us Research Program. Osteoarthritis, a degenerative joint disease, commonly affects joints like the knees and hips, causing significant pain and limiting mobility. We hypothesize that lower SES is associated with accelerated OA progression due to factors such as increased occupational hazards, limited healthcare access, and delayed early interventions.

Methodology: Data was sourced from the All-of-Us database, encompassing X-rays, clinical symptoms, and demographic information. The study population includes individuals diagnosed with OA in weight-bearing joints. SES indicators include income level, education, employment status, and area-based SES metrics, while OA progression is measured by changes in X-ray findings (e.g., joint space narrowing, osteophyte formation) and symptom severity over time. Participants were categorized into low, medium, and high SES tiers, and regression analysis was employed to compare progression rates

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