VCOM 2024 Annual Report

adipocyte function to the development of hyperglycemia in coronavirus infection. Dr. DiGuiseppe is Co-PI with Melissa Lipsmeyer, PhD. Investigators are Lin Kang, PhD and Kasia Michalak, MS. Zakaria Abd Elmageed, PhD • Delta-CRP: Targeting SUMOylation Pathway To Sensitize Castration-Resistant Prostate Cancer Cells To Enzalutamide Treatment. Dr. Elmageed serves as PI on this project along with a collaborator from the University Louisiana Monroe College of Pharmacy. Melissa Lipsmeyer, PhD • REAP: Investigating the contribution of aberrant adipocyte function to the development of hyperglycemia in coronavirus infection. Dr. Lipsmeyer and Stephen DiGuiseppe, PhD are Co-PIs. Investigators are Lin Kang, PhD and Kasia Michalak, MS. K. Adam Morrow, PhD • Delta-CRP: Olive oil phenolics as novel protectants against

nosocomial pneumonia. Dr. Morrow leads this project as PI together with a collaborator at University Louisiana Monroe College of Pharmacy. Pawel Michalak, PhD • VCOM/VMCVM One Health Program: SARS-CoV-2 emergence and subsequent spillover to animal reservoirs: A One Health approach to a global public health crisis. Dr. Michalak is Co-PI on this project with a collaborator from VMCVM. Lin Kang, PhD serves as an investigator. Ramu Anandakrishnan, PhD • REAP: Preliminary validation of a blood-based screening assay for lung cancer. Dr. Anandakrishnan is Co-PI with a Carilion Clinic physician, and Robin Varghese, PhD is an investigator. Blaise Costa, MPharm, PhD • VCOM/ICTAS Matching Program: To Study Traumatic Virginia Campus

Brain Injury Induced Oscillation of Glutamate Pendulum & Chemical Clamps to Hold. Dr. Costa serves as Co-PI on this project with a faculty member from Biomedical Engineering and Mechanics. This is a 1:1 funding match program with Virginia Tech. Fred Rawlins II, DO • REAP: Application of a Novel Voice Recognition-based Analytical Classification Model in Analysis of Medical Student Medical Decision-Making During Case Presentation. Taylor Daniels, Kim Gittings, and Janella Looney are investigators on this project. Kelly Roballo, DVM, PhD • VCOM/ICTAS Matching Program: Characterization of blast spinal cord injury as an animal model for back pain. Dr. Roballo serves as Co-PI on this project with a faculty member from Biomedical Engineering and Mechanics. This is a 1:1 funding match program with Virginia Tech. Chris Reilly, PhD • VCOM/VMCVM One Health Program: Delineating the pathogenic role of transcription factor EGR2 on B cell differentiation and function in lupus. A collaborator from VMCVM serves as Co-PI with Dr. Reilly on this project.

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