VCOM 2022 Annual Report

Carolinas Campus Stephan Brown, MD, PhD • VCOM & VMCVM One Health Program: Utilizing Novel Model Systems to Define Novel Mechanisms Controlled by the Unique Kinase NIK during Colorectal Cancer. Dr. Brown serves as Co-PI along with Jon Hagar, PhD and a colleague at VMCVM. JuliSu Dicmucci-Ward, PhD • REAP: Pilot project to investigate measurement fidelity during early growth monitoring of South Carolina infants. Dr. DiMucci-Ward is a Co-PI on this project with Steven Enkemann, PhD. Steven Enkemann, PhD • REAP: Pilot project to investigate measurement fidelity during early growth monitoring of South Carolina infants. Dr. Enkemann is a Co-PI on this project with JuliSu DiMucci Ward, PhD. Patrick Fisher, PhD • REAP: Effects of plant based AdipoR1 agonists on Insulin independent Glucose Transport in Skeletal Muscle Cells. Jon Hagar, PhD • VCOM & VMCVM One Health Program: Utilizing Novel Model Systems to Define Novel Mechanisms Controlled by the Unique Kinase NIK during Colorectal Cancer. Dr. Hagar serves as Co-PI along with Stephan Brown, MD, PhD and a colleague at VMCVM. • REAP: Interrogation of T cell regulation by CBL family ubiquitin ligases to identify novel immunotherapy strategies.

cancer. Dr. McCullough serves as Co-PI in partnership with her collaborator at AU Chemical Engineering. Darren Beck, PhD is an investigator. Nathan Neufeld, DO • VCOM & VMCVM One Health Program: Characterizing the analgesic, ablative, and oncologic outcomes after histotripsy ablation of osteosarcoma in an orthotopic murine model. Dr. Neufeld is Co-PI on this project with a collaborator from VMCVM. Gary Mount, PharmD is an investigator. Clay Pandorf, PhD • REAP: Characterizing the structure to-function relationship of a novel antisense long non-coding RNA associated with the type I/ β myosin heavy chain gene of skeletal and cardiac muscle for potential drug targeting. A collaborator from AU Biological Sciences serves as Co-PI on the project. This is a multi-year study and continues into 2022. Mayra Rodriguez, PhD • REAP: Mom strEss & chilD heALth (MEDAL) Study: A mixed-methods approach to the associations between maternal experiences and child toxic stress response in Black/African-American families. Investigators on this project are Mary Ann Taylor, PhD; Rian Anglin, MD; David Stephen, DO and Theresa McCann, PhD Richard Virgilio, DO • VCOM AUBE (matching funds from Auburn University Samuel Ginn College of Engineering): Identifying and mitigating the underlying causes of physician and nurse burnout at UAB Health System. A collaborator from AU Industrial Systems Engineering serves as Co PI, and a faculty member from AU Industrial Systems Engineering is an investigator on the project.

VCOM Funded Seed

Grants Through 6/30/21 Auburn Campus

Darren Beck, PhD • VCOM & AUCVM One Health Program: Regulation of Luteinizing Hormone to Prevent Cognitive Decline of Reproductive Senescence and Alzheimer’s Disease. Dr. Beck serves as Co-PI with a collaborator at AUCVM. Kenny Brock, DVM, PhD • VCOM & AUCVM One Health Program: CD47-mimicking phage peptide constructs for anti-cancer vaccinations. Dr. Brock serves as Co-PI in partnership with his collaborator at AUCVM. This is a multi-year study and continues into 2022. • VCOM AUBE (matching funds from Auburn University Samuel Ginn College of Engineering): Detection of Urinary Tract Infections Using Magnetostrictive Particle Biosensor Technology. Dr. Brock serves as Co-PI his collaborator at AU Engineering. Jon Commander, MD • REAP: A novel clinical tool for neuropathic grade assessment. Dr. Commander serves as Co-PI of this project along with a faculty member from AU Mechanical Engineering. Kenny Brock, DVM, PhD, and a faculty member from AU Mechanical Engineering are investigators on this study. Danielle McCullough, PhD • VCOM AUBE (matching funds from Auburn University Samuel Ginn College of Engineering): A high-density lipoprotein cholesterol nanoparticle mimic for the early detection and treatment of prostate

Zoltan Hajdu, MD • REAP: Origin of the left

common carotid artery from the brachiocephalic trunk results in increased endothelial thickening facilitated by bone marrow-derived hematopoietic progenitor cells.

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RESEARCH