VCOM 2019 Annual Report

Steve Enkemann, PhD • VCOM REAP Award: Comprehensive genetic testing as a mechanism for reducing toxicity and adverse events in colon cancer patients treated with irinotecan. Alexis Stoner, PhD, MPH • VCOM REAP Award: The implicit elephant in medical education: improving resident and student learning outcomes through implementing a clinical-educator curriculum. Dr. Stoner serves as Co-PI on this project along with a colleague from Orange Park Medical Center. funds from VT ICTAS): Investigating the physiological effects of cranial osteopathic manipulative medicine on mild traumatic brain injury. Dr. Brolinson is Co-PI on this project with a collaborator from VT Biomedical Engineering. Natalie Hyppolite, DO is an investigator. • VCOM REAP Award (matching funds from VT ICTAS): Innovative strategies for fall prevention using osteopathic evaluation and balance training. A collaborator from VT Industrial and Systems Engineering serves as Co- PI along with Dr. Brolinson. David Woodson, DO is an investigator as are faculty from VT Engineering. precision medicine to the anatomy lab. Robin Varghese, PhD is the Co- PI on this project and Skip Garner, PhD; John Anstrom, PhD and Ramu Anandakrishnan, PhD are investigators. Blaise Costa, MPharm, PhD • VCOM REAP Award: Novel cranial mechanisms for improving brain metabolic waste clearance in Alzheimer’s disease. Gunnar Brolinson, DO and Hope Tobey, DO and a colleague at VMCVM serve as investigators. • VCOM REAP Award: Synthesis and pharmacological evaluation of Virginia Campus P. Gunnar Brolinson, DO • VCOM REAP Award (matching Tiffany Carpenetti, PhD • VCOM REAP Award: Bringing

GluN1/2A/2B triheteromeric NMDA receptor selective modulators.

molecular pathways that lead to liver failure during sepsis using humanized mice and multi-cellular 3D organotypic human liver cultures. Dr. Rajagopalan serves as Co-PI along with a colleague from VT ICTAS. • VCOM & VMCVM One Health Research Center Award: Profiling of human innate as well as adaptive immune responses to Brucella infection and vaccination using humanized mice to predict protective outcomes. A faculty member from VMCVM serves as Co-PI along with Dr. Rajagopalan. Chris Reilly, PhD • VCOM & VMCVM One Health Research Center Award: Early growth response protein 2 (EGR2)-mediated epigenetic regulatory network in lupus. Dr. Reilly is Co-PI with a faculty member at VMCVM. • VCOM & VMCVM One Health Research Center Award: Modulation of the microbiota decreases disease in lupus mice. A colleague from VMCVM serves as Co-PI with Dr. Reilly on this project. Beverly Rzigalinski, PhD • VCOM REAP Award: Improving blood storage with cerium oxide nanoparticles. • VCOM REAP Award (matching funds from VT ICTAS): Evidence based approach for modeling osteopathic manipulative therapy in a rodent model. Dr. Rzigalinski serves as Co-PI with a colleague from VT Bioengineering and Mechanics. Al Kozar, DO is an investigator on this study. Dean Sutphin, PhD • VCOM REAP Award: Third-generation DNA sequencing approaches to rapid characterization of drinking water contamination in Appalachia. Skip Garner, PhD and Pawel Michalak, PhD are investigators on this project. Robin Varghese, PhD • VCOM REAP Award: Bringing precision medicine to the anatomy lab. Tiffany Carpenetti, PhD is the Co-PI on this project and Skip Garner, PhD; John Anstrom, PhD and Ramu Anandakrishnan, PhD are investigators.

Skip Garner, PhD • VCOM REAP Award: Evidence-based optimization of the Bredesen protocol for diminished mental capacity. Dixie Tooke- Rawlins, DO is the Co-PI, and Selen Olgun, MD, PhD, Nick Kinney, PhD, Robin Varghese, PhD and a clinician at a private health clinic are investigators on this project. Terry Hrubec, DVM, PhD • VCOM REAP Award: Establishing toxicological endpoints with human QAC exposure. Teresa Johnson, PhD • VCOM REAP Award: Isolation of antiviral and hemostatic factors from a naturally- occurring substance for treatment of viral infections and wounds of the dermis. Jim Mahaney, PhD is an investigator on this study. Susan Meacham, PhD • VCOM REAP Award: Nutritional status in VCOM international service areas: a comparative analysis. Dean Sutphin, PhD, JuliSu Dimucci-Ward and Annie Kirby, PhD, RN are investigators on this project. Pawel Michalak, PhD • VCOM REAP Award: IGPOHOM: An integrative genomics platform for one health and osteopathic medicine. Skip Garner, PhD is an investigator on this study. • VCOM & VMCVM One Health Research Center Award: Integrative genomics of small noncoding RNAs in host- associated bacteria – Phase II. Dr. Michalak is Co-PI on this project with a colleague from VMCVM. • VCOM & VMCVM One Health Research Center Award: Nanopore-based deep sequencing to characterize Ixodes scapularis variants and their pathogenic microbiota. Dr. Michalak is Co-PI on this project with a colleague from VMCVM. Govind Rajagopalan, PhD • VCOM REAP Award (matching funds from VT ICTAS): Delineating the

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SCHOLARLY ACTIVITIES