VCOM 2019 Annual Report

Funded Research 2018-2019 VCOM Extramural Funded Active Research Projects (continued)

VCOMFunded Seed Grants New in 2018 (Start date: 7/1/18) Auburn Campus Kenny Brock, DVM, PhD • VCOM & AUCVM One Health Program Award: Phage-peptide constructs as substitute for anti-cancer monoclonal antibody therapy: CD47-based model. Dr. Brock serves as Co-PI in partnership with his collaborator at AUCVM. Three faculty from the AUCVM are investigators on the project. Jonathan Commander, MD • VCOM REAP Award: A novel clinical tool for neuropathic grade assessment. Dr. Commander’s Co-PI is at AU Mechanical Engineering. Wei Liu, PhD and a faculty member from AU Mechanical Engineering are investigators on this study. evaluation of the pelvic organ prolapse repairs using Cine-MRI. Kraig Smith, MD and a colleague from AU Electrical and Computer Engineering are Co-PIs on this study along with Dr. Harris. Annie Kirby, PhD, RD • VCOM REAP Award: The effect of macronutrient cycling on metabolic flexibility in the Kenneth Harris, MD • VCOM REAP Award: Post-surgical

work. Faculty from AU Kinesiology and Nutrition departments are also investigators. Wei Liu, PhD • VCOM REAP Award: Objective assessment of knee joint stiffness as a functional outcome measure of osteopathic manipulative treatments (OMT) for chronic joint pain. Jos Edison, DO and Abdullah Siraj, DO are investigators. Cinzia Mastrorilli, DVM, PhD • VCOM & AUCVM One Health Program Award: Quantification of canine hematopoietic stem cells after peripheral mobilization and concentration for orthopedic point of care applications in human and veterinary medicine. Dr. Mastrorilli is Co-PI on this project along with a colleague at AUCVM. evaluation of the pelvic organ prolapse repairs using Cine-MRI. Kenneth Harris, MD and a colleague from AU Electrical and Computer Engineering are Co-PIs. Kaelin Young, PhD • VCOM & AUCVM One Health Program Award: Examining the effects of skeletal muscle LINE-1 overexpression on muscle function and aging. Collaborators from AUCVM and AU Kinesiology are Dr. Young’s Co-PIs on this study. Other investigators are from AU School of Pharmacy and Kinesiology Department. Stephan Brown, MD, PhD • VCOM & VMCVM One Health Research Center Award: Top-down or bottom-up tumorigenesis: defining the role of non- canonical NF- κ B signaling in colorectal cancer. A collaborator from VMCVM serves as Co-PI with Dr. Brown on this project. Kraig Smith, MD • VCOM REAP Award: Post-surgical Carolinas Campus

Chris Reilly, PhD • Acetylon Pharmaceuticals (funding through Virginia Tech): Inhibition of SLE with the HDAC-6 Inhibitor ACY-1083 in NZB/W female mice. • National Institutes of health (funding to Virginia Tech): Effect of maternal immune factors in shaping the infant gut microbiota. Ward Stevens, DHSc • Wythe-Bland Foundation: The Edward Via College of Osteopathic Medicine (VCOM) Physician Educator Retention Program

Virginia Campus Student Award

Katie Slaymaker, Class of 2019 • American Osteopathic Association (AOA) Student Research Training Grant: Inviting interdisciplinary input: An osteopathic approach to leveraging community support for prevention and management of chronic disease in rural and Appalachian Virginia. Susan Meacham, PhD served as the faculty mentor on this project.

presence of excess adiposity. Kaelin Young, PhD is an investigator on this

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