VCOM 2018 Annual Report

conjunction with a collaborator at Virginia Tech’s Biomedical Engineering and Mechanics. • VCOM & VMCVM One Health Research Center Award: In vivo eccentric loading therapy to treat Achilles tendinopathy; a faculty member from VMCVM serves as Co-PI with Dr. Brolinson on this study. Blaise Costa, MPharm, PhD • VCOM REAP Award: Novel cranial mechanisms for improving brain metabolic waste clearance in Alzheimer’s disease; Hope Tobey, DO and P. Gunnar Brolinson, DO are VCOM investigators on this project. An investigator from VMCVM is also involved. • VCOM & VMCVM One Health Research Center Award: The role of tri-heteromeric (GluN1/2/3) NMDA receptors in stroke and its mitigation; Dr. Costa is a Co-PI with a collaborator from Virginia Tech’s VMCVM. Skip Garner, PhD & John Anstrom, PhD • VCOM REAP Award: Bringing precision medicine to anatomy lab; Robin Varghese, PhD is an investigator on this study. Research Center Award: Balancing the maternal microbiota-perinatal neuroimmune axis: Implications for neurodevelopmental disorders. Dr. Hrubec is serving as Co-PI with a collaborator from VMCVM. Teresa Johnson, PhD • VCOM REAP Award: Development of a point-of-care diagnostic kit for bacterial and viral pneumonia; Renee Prater, DVM, PhD is the Co-PI on this project and two Carilion Medical Center physicians are also involved as investigators. OMS II Michael Epps and OSM II Leo Druker are student investigators on the project. Terry Hrubec, DVM, PhD • VCOM & VMCVM One Health

• VCOM & VMCVM One Health Research Center Award:

Developing a lamb model for the study of human and bovine RSV disease; Renee Prater, DVM, PhD and a researcher from VMCVM serve as Co-PIs on this study. Nick Kinney, PhD • VCOM REAP Award: Using known genetic variants to enhance cancer prevention in the US and abroad; Skip Garner, PhD is an investigator on this work. Al Kozar, DO, FAOASM, RMSK • VCOM REAP Award: Acquisition of a real-time shear wave ultrasound elastography system for translational musculoskeletal research; Dr. Kozar serves as Co-PI along with a colleague at Virginia Tech’s Biomedical Engineering and Mechanics. Pawel Michalak, PhD • VCOM REAP Award: Integrative genomics platform for osteopathic medicine. • VCOM & VMCVM One Health Research Center Award: Integrative genomics of small noncoding RNAs in host- associated bacteria; Dr. Michalak is collaborating with a Co-PI from Virginia Tech’s VMCVM. Jim Palmieri, PhD • VCOM & VMCVM One Health Research Center Award: Improved diagnosis of acute and chronic Lyme disease in humans and dogs; Christina Kozar, DO, Al Kozar, DO and Lindsay Call, DO are VCOM Investigators on this project. A collaborator from VMCVM serves as Co-PI with Dr. Palmieri, and there are three VMCVM investigators involved with the work. Renee Prater, DVM, PhD • VCOM REAP Award: Development of a point-of-care diagnostic kit for bacterial and viral pneumonia; Teresa Johnson, PhD is the Co-PI on this project and two Carilion Medical Center physicians are also involved as investigators. OMS II

Michael Epps and OSM II Leo Druker are student investigators on the project. • VCOM & VMCVM One Health Research Center Award: Developing a lamb model for the study of human and bovine RSV disease; Teresa Johnson, PhD and a researcher from VMCVM serve as Co-PIs with Dr. Prater on this study. Chris Reilly, PhD • VCOM & VMCVM One Health Research Center Award: Early growth response protein 2 (EGR2)-mediated epigenetic regulatory network in lupus; Dr. Reilly is Co-PI along with a colleague from VMCVM. In addition, two investigators from VMCVM are also collaborating on this project. Mark Rogers, DO, CAQSM • VCOM REAP Award: Reconstructions of concussive impacts in football; Dr. Rogers serves as Co-PI with a collaborator from Virginia Tech’s Biomedical Engineering and Mechanics. Robin Varghese, PhD • VCOM REAP Award: Whole exome sequencing reveals microsatellite markers for atrial fibrillation; two physicians from Carilion Medical Center serve as Co-PIs on this project, and Skip Garner, PhD is an investigator.

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NATIONAL AND GLOBAL RESEARCH