VCOM 2018 Annual Report

Funded Research VCOM Funded Seed Grants New in 2017-18

Wei Liu, PhD • VCOM REAP Award: Biofeedback Tai Chi for knee osteoarthritis: A mechanistic study; a researcher from a software and biomechanics company serves as an investigator on this project. Sara Ziska, DVM, PhD • VCOM & AUCVM One Health Program Award: Assessing the public health risk of Zika virus in Alabama; Dr. Ziska serves as Co-PI in partnership with her collaborator at AUCVM. Carolinas Campus lymphatic pump technique on wound healing in a colitis model of IBD; Zoltan Hajdu, MD and Ron Januchowski, DO are investigators on this study and OMS II Elexander Atkinson serves as a student researcher. Zachary Barcroft is the research technician on the study. • VCOM & VMCVM One Health Research Center Award: The contribution of NLR proteins in modulating gastrointestinal inflammation following exposure to wheat gluten; Dr. Berglind serves as Co-PI along with her collaborator at VMCVM. Jillian Bradley, PhD • VCOM REAP Award: The effect of facial effleurage on acute bacterial rhinosinusitis; Matthew Cannon, DO, Alexis Stoner, PhD, MPH, Randy Gregg, PhD, Liang Shan, PhD, and Jennifer Arnold serve as investigators. OMSII Lauren Needell and OMSII Clara Hitchcock are student investigators. Stephan Brown, MD, PhD • VCOM REAP Award: Role of LGR5 in adenocarcinoma stem cell survival and proliferation; Katherine Baumgarner is involved with this work and OMS II Sanjay Agarwal is a student researcher on the project. Jennifer Berglind, PhD • VCOM REAP Award: Effect of the

Jack Caldwell, PhD • VCOM REAP Award: Identifying the interaction of sex hormone binding globulin and estradiol receptor- β at the plasma membrane and within the cell; Scott Ochs, PhD, Zoltan Hajdu, MD and Stephan Brown, MD, PhD are investigators on this project. Katherine Baumgarner is involved and OMS II Reed Watts, OMS III Kevin Londe, OMS III Andrew Slater, OMS I Emily Medhus and OMS I Ng Zui are student researchers. abdominal lymphatic pump technique in enhancing CD8+ T cell responses and adoptive cell therapy for cancer; Jillian Bradley, PhD serves as an investigator, OMS II Courtney Caroti and OMS III Eric Bradley are student researchers, and Jennifer Arnold is the lab manager on the project. Zoltan Hajdu, MD • VCOM REAP Award: Hematopoietic- derived cells are blocking EMT during heart valve development; OMS II Daniel Gonzalez is a student researcher on this project. Randy Gregg, PhD • VCOM REAP Award: Efficacy of

Auburn Campus

Courtney Gamston, ScM, PharmD, BCPS • VCOM REAP Award: Evaluation of opioid metabolism in chronic pain patients; OMS-III Paulette Coombs and OMS III Michael Oberle are student researchers on this work. Researchers from a medical center and Auburn University’s Harrison School of Pharmacy and College of Veterinary Medicine are investigators. Michael Goodlett, MD • VCOM REAP Award: Biomechanics, biomarkers, and MRI: A three-pronged approach to predicting anterior cruciate ligament (ACL) rupture; Kaelin Young, PhD is an investigator on this project. Other investigators are from Auburn University Mechanical Engineering and the MRI Research Center as well as UAB Biostatistics. Josh Hollingsworth, PharmD, PhD • VCOM REAP Award: A mobile health and wellness coaching intervention for weight loss; Courtney Gamston, PharmD and Annie Newton, PhD are project investigators. Faculty from the Auburn University Harrison School of Pharmacy serve as advisors on the project.

Cindy McKinney, PhD • VCOM REAP Award: X-linked

cardiomyopathy: Molecular and cellular evaluation of CRISPR generated isogenic models of Danon disease; Katherine Baumgarner is the research lab specialist.

Virginia Campus

Ramu Anandakrishnan, PhD • VCOM REAP Award: Identifying the multi- hit combinations of inherited and somatic mutations in childhood cancers; Robin Varghese, PhD, Skip Garner, PhD and Liang Shan, PhD are investigators on this study. P. Gunnar Brolinson, DO • VCOM REAP Award: Gender-specific differences in concussion tolerance; Dr. Brolinson is Co-PI on this study in

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