Auburn Research Day 2022

Educa t i ona l Resea rch | Gr adua te / Undergr adua te St udent Investigating the Pharmacological Potential of Abrus Precatorius (Fabaceae)

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Keyi Liu; Surekha Kaddanagari; Sindhu Ramesh; Timothy Moore; Muralikrishnan Dhanasekaran Department of Drug Discovery and Development, Auburn University Harrison School of Pharmacy

Abrus precatorius is found and used in India, China, and Africa. Roots, seeds, stems, and leaves have been used traditionally because they possess antibacterial, anti-inflammatory, anti- tumor, hepatoprotective, antiparasitic, contraception, anti-allergic, antioxidant, and antihyperglycemic effects. Contemporary scientists are elucidating the bioactivity by separating the active non-toxic phytochemicals from the extracts of the different parts of the plants.

Among them, abrin is one of the characteristic products which is extracted in the seeds and is known for its toxicity. As a type II ribosome-inactivating proteins (RIPs), has the ability to inhibit cell growth and has anti-tumor activity. Furthermore, in this study, we examine their effect on the central nervous system, eye, respiratory tract, cardiovascular system, gastrointestinal tract, renal system, sexual activity, muscles, endocrine system, and immune system.

Cl i n i ca l Case Repor t | Med i ca l St udent Abdominal Leiomyoma in a 52-Year-Old Male 34

(1) Taylor L. Phillips, BS; (2) Andrew M. Frey, DO; (3) Timothy L. Christopher, MD, FACS (1) VCOM-Auburn; (2) Brookwood Baptist Health, Birmingham, AL; (3) Grandview Medical Center, Birmingham, AL

A 52-year-old male patient presented with left lower quadrant and suprapubic pain for five days. During this period, the patient reported worsening abdominal pain, decreased oral intake, and constipation. Initial imaging identified a large cystic mass within the abdominal cavity. Surgical exploration demonstrated a giant cystic lesion with calcified components attached to the small bowel. The mesenteric mass and a portion of the small bowel were resected.

The final pathology report revealed a 20 x 16 x 6 cm spindle cell lesion with no cellular atypia and a mitotic rate of <1 mitosis per 5.0 mm2. Immunohistochemical stains were positive for SMA, MSA, and desmin. Stains were negative for S-100, CD117, DOG1, and <1% for Ki-67. This led to the diagnosis of a leiomyoma. Leiomyomas are primarily found within the female reproductive tract, thus making this an unusual case.

S imu l a t i on Resea rch | Med i ca l St udent Do Medical Students Feel Adequately Prepared to Discuss LGBTQ+ Related Topics in Healthcare Today: A Survey Study 35

Matthew Khaleghi; David Kashmer Edward Via College of Osteopathic Medicine – Auburn Campus (Simulation Department)

How well do doctors know their patients? Is the future generation of doctors prepared for real-world patient encounters? According to a 2021 poll by GALLUP, 5.6% of Americans self-identify as members of the LGBT community 1 . However, more than 50% of LGBT people experience some form of healthcare discrimination 2 . This brings up whether doctors in healthcare today are competent in discussing LGBTQ+ related health services. We sought to see if current medical students feel adequately prepared to discuss some of these issues during their standardized patient exams. Second- year medical students were asked to fill out a short survey following their standardized patient exams to see how prepared they felt for an encounter involving a standardized patient identifying as a member of the LGBTQ+ community. Data was collected from all students participating in the standardized patient exam on 12/7/2021. The survey given to the medical students had one question: “Do you feel adequately prepared to discuss LGBTQ+ related topics in healthcare today?” with a yes or no checkbox. Response (1) was “yes.” If the student selected no, there was a list of six boxes to check for potential reasons why they chose

“no.” The five checkboxes were as follows: (2) I have not received adequate education regarding LGBTQ+ related matters, (3) I have received adequate education regarding LGBTQ+ matters, but am not confident in applying it clinically, (4) I have received adequate education regarding LGBTQ+ matters, but I have not had a chance to apply it clinically, (5) I believe LGBTQ+ issues in healthcare are not much different than heterosexual issues, (6) I am not comfortable discussing LGBTQ+ related matters, and (7) Other. Results revealed a total of 153 responses from the students: 83 for response 1, 42 for response 2, 8 for response 3, 18 for response 4, 2 for response 5, and zero responses for both options 6 and 7. Overall, 54% of medical students said they felt adequately prepared to discuss LGBTQ+ matters in a clinical setting, whereas 46% said they did not. The most common reason students selected that they did not feel prepared for an encounter with an LGBTQ+ patient was a lack of adequate education (60% of “no” responses). Additional investigation into an education intervention could improve the number of “yes” responses and lead to better outcomes in the simulation department examinations.

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